The Dutch National Research Agenda is based on questions from Dutch public to science. In this agenda 140 overarching questions are presented. The initiative intends to build a bridge across the entire chain of research and innovation. The Ministry of Education, Culture and Science has asked NWO to take responsibility for the Agenda and set up a programme to support it. The research is  meant to be cross-disciplinary. Big Science is connected to the questions of the Research Agenda as well. Information on the developments of the European and of the Dutch Roadmap for Research Infrastructure will be given.